Mental health guide
Mental Health Conditions: Common Types, Symptoms, Causes, and Treatment
Mental health conditions are diagnosable disturbances in thinking, emotion regulation, or behavior. This guide covers the common types by DSM-5-TR category, their signs, causes, diagnosis, treatment, and when to get help.
By Paul James Roeser·18 min read
Published ·Updated
A mental health condition, also called a mental illness, mental disorder, or psychiatric disorder, is a clinically significant disturbance in a person's thinking, emotion regulation, or behavior that causes distress or impairs daily functioning. The World Health Organization (WHO) defines a mental disorder this way, and the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR), published in March 2022, sets the diagnostic criteria clinicians in the United States use.
The 2024 National Survey on Drug Use and Health (NSDUH), published by the Substance Abuse and Mental Health Services Administration (SAMHSA), found that 23.4 percent of U.S. adults, or 61.5 million people, had any mental illness in the past year. Another measure, serious mental illness, counts conditions that substantially limit one or more major life activities, and it affected 5.6 percent of adults, or 14.6 million people. Worldwide, the WHO reports that nearly 1 in every 7 people, 1.2 billion in 2023, were living with a mental disorder.
What Are the Most Common Mental Health Conditions?
The most common mental health conditions are anxiety disorders and depressive disorders, according to the WHO, followed by trauma-related, bipolar, obsessive-compulsive, psychotic, personality, eating, neurodevelopmental, and sleep-wake disorders. Among U.S. adults, the highest past-year prevalence belongs to any anxiety disorder, at 19.1 percent, followed by a major depressive episode, at 8.2 percent.

The DSM-5-TR groups psychiatric diagnoses into chapters by shared features, and the 10 groups below contain the most widely recognized diagnoses. Comorbidity, meeting criteria for more than one condition at once, crosses these chapters, which is why prevalence figures for separate conditions do not add up to a total.

Anxiety Disorders
Anxiety disorders are conditions in which fear or worry is excessive, persistent, and out of proportion to the situation. The National Institute of Mental Health (NIMH) estimates that 19.1 percent of U.S. adults had an anxiety disorder in the past year, and 31.1 percent experience one in their lifetime. Worldwide, the WHO counted 470 million people living with an anxiety disorder in 2023, including 146 million children and adolescents. The group includes generalized anxiety disorder, panic disorder, social anxiety disorder, and agoraphobia.
Specific phobia is the anxiety disorder tied to one object or situation, such as heights, flying, or needles. Fear of the trigger is immediate, and the anxious response drives avoidance that limits daily life.
Depressive Disorders
Depressive disorders are defined by persistent sadness, emptiness, or loss of interest that impairs function. Major depressive disorder requires at least two weeks of depressed mood or loss of pleasure alongside changes in sleep, appetite, energy, concentration, or self-worth. In 2024, 8.2 percent of U.S. adults, or 21.4 million people, had a past-year major depressive episode, according to NSDUH, and the WHO counted 322 million people living with depression worldwide in 2023. Persistent depressive disorder is the chronic form, with depressed mood on most days for at least two years.
Bipolar and Related Disorders
Bipolar disorder is a mood condition with episodes of mania or hypomania, periods of elevated or irritable mood and increased energy, that alternate with depressive episodes. NIMH estimates that 2.8 percent of U.S. adults had bipolar disorder in the past year, and the WHO counted 36 million people with the condition worldwide in 2023, including 3.3 million adolescents aged 10 to 19. Bipolar I disorder requires at least one manic episode; bipolar II disorder requires hypomania and major depression.
Trauma- and Stressor-Related Disorders
Post-traumatic stress disorder develops after exposure to actual or threatened death, serious injury, or sexual violence, and its symptoms last more than one month. The four symptom clusters are intrusive memories, avoidance, negative changes in mood and thinking, and changes in arousal and reactivity. NIMH estimates that 3.6 percent of U.S. adults had post-traumatic stress disorder in the past year. Not every traumatized person develops PTSD, and adjustment disorders cover distress after stressors that fall short of traumatic stress.
Obsessive-Compulsive and Related Disorders
Obsessive-compulsive disorder pairs obsessions, intrusive and unwanted thoughts, urges, or images, with compulsions, repetitive behaviors or mental acts performed to reduce the distress the obsessions cause. NIMH estimates that 1.2 percent of U.S. adults had obsessive-compulsive disorder in the past year.
The same DSM-5-TR chapter includes body-focused repetitive behaviors. Trichotillomania, recurrent hair pulling that causes hair loss despite attempts to stop, is the most widely recognized of them.
Schizophrenia Spectrum and Other Psychotic Disorders
Schizophrenia is a psychotic disorder defined by delusions, hallucinations, disorganized speech, grossly disorganized behavior, or negative symptoms such as reduced emotional expression, with continuous signs lasting at least six months. NIMH reports U.S. prevalence estimates for schizophrenia and related psychotic disorders between 0.25 and 0.64 percent. The WHO puts the global figure at about 27 million people, or 1 in 300, and reports that people with schizophrenia die on average nine years earlier than the general population. The WHO lists medicines, psychoeducation, family interventions, and psychosocial rehabilitation as effective treatments for psychosis in schizophrenia. Schizoaffective disorder combines symptoms of schizophrenia with major mood episodes.
Personality Disorders
A personality disorder is an enduring pattern of inner experience and behavior that deviates from cultural expectations, begins by adolescence or early adulthood, and causes distress or impairment. Borderline personality disorder is marked by unstable relationships, self-image, and emotions with marked impulsivity, and NIMH estimates its past-year prevalence among U.S. adults at 1.4 percent. The DSM-5-TR diagnoses it when at least five of nine criteria are present. Narcissistic and paranoid personality disorder belong to the same chapter.
Feeding and Eating Disorders
Eating disorders are persistent disturbances of eating behavior that impair physical health or psychosocial function. The three most widely recognized eating disorders are anorexia nervosa, bulimia nervosa, and binge-eating disorder. Anorexia nervosa and bulimia nervosa center on abnormal eating and preoccupation with food, body weight, and shape, according to the WHO, while binge-eating disorder centers on recurrent binges with a sense of lost control. The WHO counted 18 million people with these conditions worldwide in 2023, including 4.7 million children and adolescents, and names family-based treatment and cognitive-based therapy as effective treatments.
Neurodevelopmental Disorders
Neurodevelopmental disorders begin in the developmental period. Attention-deficit/hyperactivity disorder (ADHD) is a persistent pattern of inattention, hyperactivity, or impulsivity that interferes with function in at least two settings, and the DSM-5-TR requires several symptoms to be present before age 12. The National Institute on Drug Abuse reports that adolescents with substance use disorders have high rates of co-occurring attention-deficit/hyperactivity disorder, the pattern known as ADHD and addiction.
Sleep-Wake Disorders
Sleep-wake disorders disrupt the quality, timing, or amount of sleep and cause daytime distress or impairment. Insomnia disorder is persistent difficulty falling asleep, staying asleep, or waking too early, present at least three nights a week for at least three months. Restless legs syndrome is classified in the same DSM-5-TR chapter.
What Are the Common Signs and Symptoms of Mental Health Conditions?
The common signs of a mental health condition are changes in sleep or appetite, mood, and thinking, social withdrawal, and a drop in functioning at work, school, or home. The American Psychiatric Association (APA) lists 14 warning signs of mental illness:
- Sleep or appetite changes
- Decline in personal care
- Mood changes, including rapid or dramatic shifts in emotion
- Withdrawal from social activities
- Body pain without a clear physical cause
- Drop in functioning at school, work, or social activities
- Problems thinking, including trouble with concentration, memory, or logic
- Increased sensitivity to sights, sounds, smells, or touch
- Apathy, a loss of desire to take part in activities
- Feeling disconnected from oneself or one's surroundings
- Illogical thinking, including unusual beliefs about personal powers
- Nervousness, including fear or suspicion of others
- Unusual behavior that is out of character
- Changes in school or work performance
The APA states that one or two of these signs alone do not predict a mental illness but indicate a need for further evaluation. When a person experiences a cluster of signs at once and they cause serious problems in the ability to study, work, or relate to others, the APA advises evaluation by a physician or mental health professional.
Specific symptoms point toward specific diagnoses. Depressed mood and loss of interest point toward a depressive disorder. Racing thoughts with a reduced need for sleep point toward mania. Intrusive memories and hypervigilance after a traumatic event point toward post-traumatic stress. Hallucinations, perceptions without an external source, are a sign of psychosis and also occur in mood disorders, substance intoxication or withdrawal, and medical conditions.
How Is an Everyday Experience Different From a Symptom?
An everyday experience becomes a symptom of a psychiatric condition when it lasts longer, returns more often, and impairs functioning past the threshold a diagnosis sets. The six pairs below set an ordinary experience beside the published threshold for the related condition. The APA caveat applies to every pair: one or two signs alone do not predict a mental illness, and only a clinician applying the full criteria makes a diagnosis.
Ordinary worry or generalized anxiety disorder?
Everyday experience: worry tied to a deadline, an exam, or a family conflict that eases once the event passes. NIMH notes that occasional worry and anxiety after stressful life events are not the same as an anxiety disorder.
Threshold for the condition: worry that is hard to control on most days for at least six months, with at least three of restlessness, fatigue, trouble concentrating, irritability, muscle tension, or sleep problems.
Sadness or depression?
Everyday experience: feeling low after a disappointment or loss while interest in other parts of life stays intact.
Threshold for the condition: depressed mood or loss of interest lasting at least two weeks, with changes in sleep, appetite, energy, concentration, or self-worth that impair function.
A bad night or insomnia disorder?
Everyday experience: poor sleep before a stressful event, after travel, or during a short illness.
Threshold for the condition: difficulty falling asleep, staying asleep, or waking too early at least three nights a week for at least three months, despite the chance to sleep, with daytime distress or impairment.
Double-checking or obsessive-compulsive disorder?
Everyday experience: checking the lock or the stove a second time before leaving. NIMH notes that everyone rethinks or double-checks things sometimes.
Threshold for the condition: obsessions or compulsions that cannot be controlled even when recognized as excessive, take more than one hour a day, and cause significant problems in daily life.
Shaken after a frightening event or post-traumatic stress disorder?
Everyday experience: upsetting memories, jumpiness, or poor sleep in the first weeks after a frightening event.
Threshold for the condition: intrusion, avoidance, negative mood and thinking, and arousal symptoms that last more than one month after the trauma and impair functioning.
Grief or prolonged grief disorder?
Everyday experience: intense sorrow after a death that comes in waves. The APA notes that for most people grief symptoms decrease over time.
Threshold for the condition: for adults, at least 12 months after the death of a close person (6 months for children and adolescents), intense longing or preoccupation with at least three listed symptoms, such as identity disruption, emotional numbness, or intense loneliness, nearly every day for at least the last month.
What Causes Mental Health Conditions?
Mental health conditions result from an interaction of genetic risk, brain biology, early-life adversity, current stressors, and substance use rather than from a single cause. The weight of each factor differs by condition and by person. The five main groups of risk factors are:
- Genetics. A 2018 Danish nationwide twin study by Hilker and colleagues in Biological Psychiatry estimated the heritability of schizophrenia at 79 percent, yet identical twins shared the diagnosis in only 33 percent of pairs, so genes raise risk without determining it. A 2000 meta-analysis of five twin studies by Sullivan, Neale, and Kendler in the American Journal of Psychiatry estimated the heritability of major depression at 37 percent.
- Brain biology. Differences in brain circuits, neurotransmitter systems, and stress hormone regulation are associated with mood, anxiety, and psychotic disorders.
- Adverse childhood experiences. Adverse childhood experiences (ACEs) are potentially traumatic events before age 18, including abuse, neglect, violence in the home, and a household member with a substance use or mental health problem. The Centers for Disease Control and Prevention (CDC) reports that three in four high school students experienced one or more ACEs. Among U.S. adults, a 2023 CDC analysis of 2011 to 2020 survey data found that 63.9 percent reported at least one adverse childhood experience and 17.3 percent reported four or more, and an earlier CDC study estimated that preventing ACEs could have avoided as much as 44 percent of adult depression cases.
- Stress and environment. Trauma, loss, chronic illness, poverty, isolation, and prolonged chronic stress are stressors that raise the risk of anxiety, depressive, and trauma-related disorders.
- Substance use. Intoxication and withdrawal produce depressed, anxious, and psychotic symptoms, and the DSM-5-TR classifies substance-induced depressive, anxiety, and psychotic disorders as separate diagnoses.
At What Age Do Mental Health Conditions Usually Begin?
Age is a timing factor rather than a cause, and the onset of a mental disorder comes early in life. A 2022 meta-analysis of 192 studies by Solmi and colleagues in Molecular Psychiatry found that 34.6 percent of people with a mental disorder had onset before age 14, 48.4 percent before age 18, and 62.5 percent before age 25, with a peak age of onset of 14.5 years. Kessler and colleagues reported in the National Comorbidity Survey Replication (2005) that half of all lifetime cases start by age 14 and three fourths by age 24.

How Are Mental Health Conditions Diagnosed?
A physician, psychiatrist, psychologist, or licensed clinician diagnoses a mental health condition through a clinical interview that compares a person's symptoms, their duration, and their effect on functioning with DSM-5-TR criteria. The evaluation also rules out medical conditions, medications, and substances that mimic a psychiatric condition, so it includes a medical history and, where indicated, a physical examination and laboratory tests.
The criteria change as research does. The DSM-5-TR added one new diagnosis, prolonged grief disorder, for grief that persists at least 12 months after a death in adults and disrupts daily life. The same revision clarified the criteria sets for more than 70 disorders and added ICD-10-CM codes for suicidal behavior and nonsuicidal self-injury.
Screening questionnaires flag who needs a full evaluation; they do not diagnose. The Patient Health Questionnaire-9 (PHQ-9) asks about the nine DSM criteria for depression. Kroenke, Spitzer, and Williams reported in 2001 in the Journal of General Internal Medicine that PHQ-9 scores of 5, 10, 15, and 20 represent mild, moderate, moderately severe, and severe depression, and that a score of 10 or higher had a sensitivity and specificity of 88 percent for major depression. The seven-item Generalized Anxiety Disorder scale (GAD-7), published by Spitzer and colleagues in 2006, screens for anxiety. The PHQ-9, GAD-7, and other mental health screening tests differ in length, accuracy, and target condition.
How Are Mental Health Conditions Treated?
Mental health conditions are treated with psychotherapy, medication, or both, delivered at a level of care matched to symptom severity, safety, and daily functioning. NIMH notes that psychiatric medications are used in combination with other treatments such as psychotherapy.
Which Psychotherapies Treat Mental Health Conditions?
Psychotherapy, or talk therapy, treats mental health conditions by changing the thoughts, emotions, and behaviors that maintain symptoms. The four most widely studied approaches are:
- Cognitive behavioral therapy (CBT), which identifies and changes unhelpful thought and behavior patterns and is used for depressive, anxiety, trauma-related, and eating disorders.
- Dialectical behavior therapy (DBT), developed by Marsha Linehan for chronic suicidal behavior and borderline personality disorder, which teaches mindfulness, distress tolerance, emotion regulation, and interpersonal effectiveness.
- Eye movement desensitization and reprocessing (EMDR), a structured trauma therapy for post-traumatic stress disorder.
- Exposure and response prevention (ERP), a form of CBT for obsessive-compulsive disorder that exposes a person to obsessional triggers while preventing the compulsive response.
Which Medications Treat Mental Health Conditions?
Psychiatric medications treat symptoms by acting on brain chemistry, and NIMH groups them into five classes. Antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), treat depressive and anxiety disorders. Anti-anxiety medications treat anxiety symptoms. Stimulants treat attention-deficit and hyperactivity symptoms. Antipsychotics treat schizophrenia and other psychotic disorders and are also used in bipolar disorder. Mood stabilizers, such as lithium, treat bipolar disorder. A prescriber selects a medication by diagnosis, prior response, side effects, and other medical conditions, and adjusts it at follow-up visits.
What Are the Levels of Care for Mental Health Treatment?
A level of care is the intensity and setting of treatment. The five levels, from least to most intensive, are:
- Outpatient treatment: scheduled therapy or medication visits while a person lives at home and keeps a normal routine.
- Intensive outpatient program (IOP): structured group and individual therapy spread across the week. The Centers for Medicare & Medicaid Services (CMS) sets a minimum of nine hours of IOP services per week for Medicare patients.
- Partial hospitalization program (PHP): a day program that CMS describes as an alternative to psychiatric hospitalization, with a minimum of 20 hours of services per week.
- Residential treatment: 24-hour care in a non-hospital setting for people who need structure beyond a day program.
- Inpatient psychiatric hospitalization: 24-hour hospital care for acute safety risk, severe psychosis or mania, or symptoms that prevent basic self-care.

People move between levels as symptoms change. Step-down care moves a person from a hospital stay to a partial hospitalization or intensive outpatient program before standard outpatient care.
How Do Mental Health Conditions and Substance Use Disorders Overlap?
Mental health conditions and substance use disorders co-occur in 21.2 million U.S. adults, 8.1 percent of adults, according to the 2024 NSDUH. About one third of the 61.5 million adults with any mental illness also had a substance use disorder, and nearly half of the 14.6 million adults with serious mental illness, 6.9 million people, also had one.
The National Institute on Drug Abuse (NIDA) describes three pathways behind the overlap. Shared risk factors, including inherited characteristics, adverse social environments, trauma, and stress, contribute to both. People with mental disorders carry a greater risk of substance misuse. Substance use changes some of the same brain areas that are disrupted in schizophrenia and in anxiety, mood, and impulse-control disorders. Clinicians call the combination a dual diagnosis, and integrated treatment addresses both conditions together rather than in sequence.
How Many Adults With Co-Occurring Disorders Receive Treatment?
Two in five U.S. adults with both a mental illness and a substance use disorder, 41.2 percent or 8.8 million people, received no treatment for either condition in 2024, according to NSDUH. Another 41.0 percent received mental health treatment only, 3.2 percent received substance use treatment only, and 14.5 percent, 3.1 million people, received both. Among adults with a serious mental illness and a substance use disorder, 29.9 percent received neither. Treatment reach is higher for serious mental illness: 52.1 percent of adults with any mental illness and 70.8 percent of adults with serious mental illness were treated for their mental health in the past year.

When Should Someone Seek Help for a Mental Health Condition?
Seek a professional evaluation when a cluster of warning signs appears at once and causes serious problems at work, school, or in relationships, the threshold the American Psychiatric Association sets. A primary care physician, psychiatrist, psychologist, or licensed therapist performs the evaluation, and a screening questionnaire is a practical first step for a person unsure whether symptoms reach that point.
In 2024, 14.3 million U.S. adults, 5.5 percent, had serious thoughts of suicide in the past year, 4.6 million, 1.8 percent, made a suicide plan, and 2.2 million, 0.8 percent, attempted suicide, according to NSDUH. Of the 14.3 million adults with serious thoughts of suicide, 9.8 million had the thoughts without a plan or an attempt. Thoughts of suicide are a reason to call, text, or chat with 988 before a crisis point is reached. For adults in New Jersey comparing programs after an evaluation, the structure of intensive outpatient and outpatient mental health treatment in New Jersey is laid out by level of care.
What Are the Mental Health Conditions, From A to Z?
The 16 mental health conditions below are listed alphabetically with the feature that defines each one, followed by 5 related symptoms, stressors, and behaviors that are not diagnoses on their own. Each entry names its DSM-5-TR chapter and the symptom domains it mainly affects.
Which Mental Health Conditions Are Diagnosable Disorders?
- ADHD and addiction: How attention-deficit/hyperactivity disorder and substance use disorders overlap. (Neurodevelopmental disorders; attention, behavior and impulses)
- Anxiety disorders: Excessive fear or worry that persists and impairs daily function. (Anxiety disorders; anxiety and fear)
- Binge-eating disorder: Recurrent episodes of eating large amounts of food with a sense of lost control. (Feeding and eating disorders; eating, behavior and impulses)
- Bipolar disorder: Episodes of mania or hypomania that alternate with depressive episodes. (Bipolar and related disorders; mood, sleep)
- Borderline personality disorder: Unstable relationships, self-image, and emotions, with marked impulsivity. (Personality disorders; mood, behavior and impulses)
- Depression: Persistent depressed mood or loss of interest lasting at least two weeks. (Depressive disorders; mood, sleep)
- Eating disorders: Persistent disturbances in eating behavior that harm health and function. (Feeding and eating disorders; eating)
- Insomnia disorder: Persistent difficulty falling or staying asleep despite the chance to sleep. (Sleep-wake disorders; sleep)
- Narcissistic personality disorder: A pervasive pattern of grandiosity, need for admiration, and low empathy. (Personality disorders; behavior and impulses)
- Obsessive-compulsive disorder: Intrusive obsessions and the compulsive rituals performed to neutralize them. (Obsessive-compulsive and related disorders; anxiety and fear, behavior and impulses)
- Paranoid personality disorder: Pervasive distrust and suspicion of other people's motives. (Personality disorders; thinking and perception)
- Post-traumatic stress disorder: Intrusion, avoidance, mood, and arousal symptoms lasting more than a month after trauma. (Trauma- and stressor-related disorders; anxiety and fear, mood, sleep)
- Restless legs syndrome: An urge to move the legs at rest, worse in the evening, that disrupts sleep. (Sleep-wake disorders; sleep)
- Schizophrenia: Psychosis with delusions, hallucinations, disorganized thinking, or negative symptoms. (Schizophrenia spectrum and other psychotic disorders; thinking and perception)
- Specific phobia: Marked, persistent fear of one object or situation, out of proportion to the danger. (Anxiety disorders; anxiety and fear)
- Trichotillomania: Recurrent hair pulling that causes hair loss despite attempts to stop. (Obsessive-compulsive and related disorders; behavior and impulses)
Which Related Experiences Are Not Diagnoses on Their Own?
- Burnout: An occupational pattern of exhaustion, detachment, and reduced efficacy. (Symptoms and related experiences; mood)
- Catatonia: A psychomotor syndrome that presents in psychotic, mood, and medical conditions. (Symptoms and related experiences; behavior and impulses, thinking and perception)
- Hallucinations: Perceptions without an external source, a symptom rather than a diagnosis. (Symptoms and related experiences; thinking and perception)
- Stress: The body's response to a demand; chronic stress raises the risk of several conditions. (Symptoms and related experiences; anxiety and fear, sleep)
- Urophagia: Drinking urine, a behavior with no DSM-5-TR diagnosis of its own. (Symptoms and related experiences; behavior and impulses)
Sources & References21ShowHide
- Substance Abuse and Mental Health Services Administration. Key Substance Use and Mental Health Indicators in the United States: Results from the 2024 National Survey on Drug Use and Health (HHS Publication No. PEP25-07-007, NSDUH Series H-60), July 2025 — Adults 18+, past year, 2024: any mental illness 23.4% (61.5 million); serious mental illness 5.6% (14.6 million); major depressive episode 8.2% (21.4 million); any mental illness and a substance use disorder 8.1% (21.2 million), about one third of adults with AMI; 6.9 million of the 14.6 million adults with SMI also had an SUD; serious thoughts of suicide 5.5% (14.3 million), of whom 9.8 million had serious thoughts only; suicide plan 1.8% (4.6 million); suicide attempt 0.8% (2.2 million); 52.1% of adults with AMI (32.0 million) and 70.8% of adults with SMI (10.3 million) received mental health treatment (Figure 57). Table A.70B, adults with co-occurring AMI and an SUD: 41.2% (8.8 million) received neither substance use nor mental health treatment, 41.0% (8.7 million) mental health treatment only, 3.2% (681,000) substance use treatment only, 14.5% (3.1 million) both; adults with co-occurring SMI and an SUD: 29.9% (2.1 million) received neither.
- World Health Organization. Mental disorders, fact sheet, 11 September 2026 — A mental disorder is characterized by a clinically significant disturbance in an individual's cognition, emotional regulation, or behaviour, usually associated with distress or impairment; in 2023 nearly 1 in every 7 people (1.2 billion) were living with a mental disorder, with anxiety and depressive disorders the most common. 2023 counts (Global Burden of Disease): anxiety disorders 470 million including 146 million children and adolescents; depression 322 million; bipolar disorder 36 million including 3.3 million adolescents aged 10-19; schizophrenia about 27 million, or 1 in 300 people; eating disorders 18 million including 4.7 million children and adolescents. People with schizophrenia die on average nine years earlier than the general population; effective schizophrenia treatments include medicines, psychoeducation, family interventions, and psychosocial rehabilitation; eating disorder treatments include family-based treatment and cognitive-based therapy.
- American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR), 2022 — Diagnostic categories and criteria referenced for each condition group, including the duration criteria for major depressive disorder, PTSD, schizophrenia, and insomnia disorder. The text revision added one new diagnosis (prolonged grief disorder), clarified the criteria sets for more than 70 disorders, and added ICD-10-CM symptom codes for suicidal behavior and nonsuicidal self-injury.
- American Psychiatric Association. Prolonged Grief Disorder — Prolonged grief disorder is the newest DSM diagnosis, included in DSM-5-TR (released March 2022). Diagnosis requires the loss of a close person at least 12 months earlier for adults (6 months for children and adolescents) and at least 3 listed symptoms nearly every day for at least the last month, with grief lasting longer than social, cultural, or religious norms; for most people grief symptoms decrease over time.
- National Institute of Mental Health. Generalized Anxiety Disorder: When Worry Gets Out of Control (revised 2025) — A GAD diagnosis requires difficulty controlling worry on most days for at least 6 months and at least three of: restlessness, fatigue, trouble concentrating, irritability, muscle tension, or sleep problems; GAD is not the same as occasional worry or anxiety due to stressful life events.
- National Institute of Mental Health. Obsessive-Compulsive Disorder: When Unwanted Thoughts or Repetitive Behaviors Take Over (NIH Publication No. 23-MH-4676, revised 2023) — Everyone double-checks things sometimes; people with OCD generally cannot control their obsessions or compulsions even when they know they are excessive, spend more than 1 hour a day on them, and experience significant problems in daily life.
- American Psychiatric Association. Warning Signs of Mental Illness — Lists 14 warning signs; one or two signs alone cannot predict a mental illness but indicate a need for further evaluation.
- National Institute of Mental Health. Mental health statistics: any anxiety disorder, bipolar disorder, PTSD, OCD, schizophrenia, and personality disorders (National Comorbidity Survey Replication, 2001-2003) — Past-year prevalence among U.S. adults: any anxiety disorder 19.1% (lifetime 31.1%), bipolar disorder 2.8%, PTSD 3.6%, OCD 1.2%, borderline personality disorder 1.4%; schizophrenia and related psychotic disorders estimated at 0.25% to 0.64%.
- National Institute of Mental Health. Mental Health Medications — Covers antidepressants, anti-anxiety medications, stimulants, antipsychotics, and mood stabilizers, used in combination with other treatments such as psychotherapy.
- Kessler RC, Berglund P, Demler O, et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 2005;62(6):593-602. PMID 15939837 — Half of all lifetime cases start by age 14 years and three fourths by age 24 years.
- Solmi M, Radua J, Olivola M, et al. Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies. Molecular Psychiatry, 2022;27(1):281-295. PMID 34079068 — Onset of any mental disorder before ages 14, 18, and 25 in 34.6%, 48.4%, and 62.5% of individuals; peak age at onset 14.5 years.
- Hilker R, Helenius D, Fagerlund B, et al. Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register. Biological Psychiatry, 2018;83(6):492-498. PMID 28987712 — Heritability of schizophrenia estimated at 79%; probandwise concordance 33% in monozygotic twins.
- Sullivan PF, Neale MC, Kendler KS. Genetic epidemiology of major depression: review and meta-analysis. American Journal of Psychiatry, 2000;157(10):1552-1562. PMID 11007705 — Five twin studies; heritability of liability to major depression 37% (95% CI 31%-42%).
- Centers for Disease Control and Prevention. About Adverse Childhood Experiences — Three in four high school students reported experiencing one or more ACEs.
- Swedo EA, Aslam MV, Dahlberg LL, et al. Prevalence of Adverse Childhood Experiences Among U.S. Adults - Behavioral Risk Factor Surveillance System, 2011-2020. MMWR, 2023;72(26):707-715. PMID 37384554 — 63.9% of U.S. adults reported at least one ACE and 17.3% reported four or more (BRFSS 2011-2020, all 50 states and DC).
- Merrick MT, Ford DC, Ports KA, et al. Vital Signs: Estimated Proportion of Adult Health Problems Attributable to Adverse Childhood Experiences. MMWR, 2019;68(44):999-1005. PMID 31697656 — Population attributable fraction for depressive disorder: 44.1%; preventing ACEs could potentially have avoided up to 21 million depression cases.
- Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. Journal of General Internal Medicine, 2001;16(9):606-613. PMID 11556941 — PHQ-9 scores of 5, 10, 15, and 20 represent mild, moderate, moderately severe, and severe depression; a score of 10 or more had 88% sensitivity and 88% specificity for major depression.
- Spitzer RL, Kroenke K, Williams JB, Lowe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Archives of Internal Medicine, 2006;166(10):1092-1097. PMID 16717171 — Seven-item anxiety scale with good reliability and validity.
- Centers for Medicare & Medicaid Services. CY 2024 Medicare Hospital Outpatient Prospective Payment System and Ambulatory Surgical Center Payment System Final Rule (CMS-1786-FC), fact sheet, November 2, 2023 — Intensive outpatient program: a physician determines each patient needs a minimum of nine hours of IOP services per week; partial hospitalization: a minimum of 20 hours of PHP services per week.
- National Institute on Drug Abuse. Co-Occurring Disorders and Health Conditions — Common risk factors, including inherited characteristics, adverse social environments, trauma, and stress, contribute to substance use and other mental disorders; substance use changes some of the same brain areas disrupted in other mental disorders; adolescents with substance use disorders have high rates of co-occurring mood and anxiety disorders, conduct disorder, and ADHD.
- 988 Suicide and Crisis Lifeline — Call, text, or chat 988, 24 hours a day; Spanish speakers press 2 or text AYUDA; Deaf and hard-of-hearing users dial 988 from a videophone.


